Influence of Maternal Obesity on Insulin Sensitivity and Secretion in Offspring

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Influence of Maternal Obesity on Insulin Sensitivity and Secretion in Offspring

OBJECTIVE The purpose of this study was to clarify the effects of maternal obesity on insulin sensitivity and secretion in offspring. RESEARCH DESIGN AND METHODS Fifty-one offspring of both sexes of obese (Ob group) and 15 offspring of normal-weight (control group) mothers were studied. Plasma glucose, insulin, and C-peptide were measured during an oral glucose tolerance test (OGTT). Insulin ...

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OBJECTIVE There is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults. We have carried out a twin study to distinguish among maternal influences, which affect both twins; fetoplacental influences, which are unique to each twin; and the genetic factors that may underlie this association. RESEARCH DESIGN AND METHODS We identified a sample of 423 ...

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Effect of maternal obesity on insulin action in male adult offspring rats

Materials and methods twelve newborn female Wistar rats were used, and half of them submitted to saline solution administration (control) and the other half were administrated monosodium glutamate solution, 4.0 mg/Kg body weight (obese) in neonatal period. At adult age (90 days of life) these female rats were mated with health male rats and the male offspring were used, divided into two groups:...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2008

ISSN: 0149-5992,1935-5548

DOI: 10.2337/dc08-0432